Monkey Puzzles

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Science  28 Jun 2002:
Vol. 296, Issue 5577, pp. 2325-2326
DOI: 10.1126/science.296.5577.2325

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Almost 2 decades after HIV was identified as the cause of AIDS, researchers are still debating which immune responses are likely to provide the best protection against the virus. The answer is proving elusive in part because experiments with monkeys are coming up with puzzling, even contradictory, data. As a growing number of vaccines move through the pipeline toward clinical trials, these experiments are raising serious questions about most of the vaccine approaches now being pursued.