Tools for the Biomolecular Engineer

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Science  05 Jul 2002:
Vol. 297, Issue 5578, pp. 62-63
DOI: 10.1126/science.1073843

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As traditional "top-down" approaches to device fabrication are reaching their limits, "bottom-up" approaches based on the assembly of individual molecules are receiving increasing attention. Biomolecules such as DNA are particularly promising because of their specific recognition capabilities. In his Perspective, Niemeyer highlights the molecular lithography approach developed by Keren et al. Combined with protein bioengineering, molecular lithography provides a new, powerful tool for using DNA in future nanometer-scale devices.