Addiction to Oncogenes--the Achilles Heal of Cancer

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Science  05 Jul 2002:
Vol. 297, Issue 5578, pp. 63-64
DOI: 10.1126/science.1073096

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A series of recent studies are providing tantalizing hints of new therapeutic approaches for combating cancer. In his Perspective, Weinstein discusses new work ( Jain et al.) demonstrating that even brief inactivation of an oncogene can permanently reverse the malignant phenotype of some types of tumor.