PerspectiveCell Biology

PARP-1--a Perpetrator of Apoptotic Cell Death?

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Science  12 Jul 2002:
Vol. 297, Issue 5579, pp. 200-201
DOI: 10.1126/science.1074592

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The caspase-dependent pathway of programmed cell death has been well documented. In their Perspective, Chiarugi and Moskowitz report on new findings ( Yu et al.) that reveal a caspase-independent pathway of apoptosis driven by the nuclear enzyme PARP-1.