Multiple Roles of Arabidopsis VRN1 in Vernalization and Flowering Time Control

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Science  12 Jul 2002:
Vol. 297, Issue 5579, pp. 243-246
DOI: 10.1126/science.1072147

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Arabidopsis VRN genes mediate vernalization, the process by which a long period of cold induces a mitotically stable state that leads to accelerated flowering during later development. VRN1 encodes a protein that binds DNA in vitro in a non–sequence-specific manner and functions in stable repression of the major target of the vernalization pathway, the floral repressor FLC. Overexpression of VRN1 reveals a vernalization-independent function for VRN1, mediated predominantly through the floral pathway integratorFT, and demonstrates that VRN1 requires vernalization-specific factors to target FLC.

  • * These authors contributed equally to this work.

  • Present address: Laboratoire de Recherche Moléculaire sur les Antibiotiques, 15 rue de l'Ecole de Médecine, 75006 Paris, France.

  • Present address: Department of Botany, La Trobe University, Bundoora, Victoria, 3083, Australia.

  • § To whom correspondence should be addressed. E-mail: caroline.dean{at}

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