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Missized Mutants Help Identify Organ Tailors

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Science  19 Jul 2002:
Vol. 297, Issue 5580, pp. 328
DOI: 10.1126/science.297.5580.328

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Two studies published this week point to genes that might optimize size in parts of the nervous system. On page 365, researchers describe the effects of a ubiquitous protein called b-catenin on the size of the brain's cerebral cortex. And in a paper published online this week by Science, another team explains how a protein called Six6 interacts with key cell-division genes to control the size of the developing retina and pituitary gland.