TOOLS: Gene Genie

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Science  26 Jul 2002:
Vol. 297, Issue 5581, pp. 483
DOI: 10.1126/science.297.5581.483d

Cancer cells often betray themselves through abnormal gene expression. SAGE Genie, a new set of computer tools hosted by the National Cancer Institute's Cancer Genome Anatomy Project, allows visitors to determine how hard particular genes are working in cancerous and normal cells. The tools draw on a database of results from the technique known as serial analysis of gene expression (SAGE), a quick way to determine which genes are active from samples of RNA. With the site's SAGE Anatomic Viewer, for instance, you can type in almost any human gene and get color-coded cartoons showing the gene's activity in healthy and malignant tissues throughout the body.

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