PerspectiveSignal Transduction

History Matters

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Science  09 Aug 2002:
Vol. 297, Issue 5583, pp. 948-949
DOI: 10.1126/science.1075222

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How do signaling networks within cells communicate with each other in order to respond to a vast array of external stimuli with the correct responses? In their Perspective, Ingolia and Murray discuss a new approach (Bhalla et al.) that elucidates the regulation of the MAPK signaling cascade in cultured cells and how cellular history contributes to this regulation.