Breaking Down Barriers

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Science  16 Aug 2002:
Vol. 297, Issue 5584, pp. 1116-1118
DOI: 10.1126/science.297.5584.1116

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The brain is guarded by a nearly impenetrable cellular barrier called the blood-brain barrier. A small but growing community of predominantly academic researchers is studying this barrier with an eye to improving drug delivery to the brain. Their research ranges from trying to better understand the basic biology to creating molecular Trojan horses that sneak anything from neural growth factors to therapeutic genes into the brain.