Contact--How Platelets Touch von Willebrand Factor

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Science  16 Aug 2002:
Vol. 297, Issue 5584, pp. 1128-1129
DOI: 10.1126/science.1075452

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The initiation of clotting at sites of vascular injury involves the adhesion of platelets to von Willebrand factor (VWF) via the surface glycoprotein GPIba. In a Perspective, Sadler discusses a new structural analysis ( Huizinga et al.) that sheds light on how platelet GPIba interacts with VWF.