It Takes More Than Two to Nogo

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Science  16 Aug 2002:
Vol. 297, Issue 5584, pp. 1132-1134
DOI: 10.1126/science.1076247

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Growth-inhibitory molecules present in the myelin sheath surrounding CNS neurons prevent the regeneration of injured nerve fibers. In a Perspective, Woolf and Bloechlinger discuss new findings published here (Liu et al.) and elsewhere revealing that three of these growth-inhibitory molecules all bind to the same receptor. This suggests that blocking this receptor may be a good therapeutic approach to promoting neuronal regeneration.