Doublesex in the Middle

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Science  16 Aug 2002:
Vol. 297, Issue 5584, pp. 1135-1136
DOI: 10.1126/science.1074492

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What are the molecular mechanisms that determine the acquisition of male and female sexual characteristics? In a Perspective, Ken Burtis reviews a series of recent papers published elsewhere that elucidate the part played by the transcription factor, doublesex, in determining sexual dimorphism in the fruit fly.