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Science  23 Aug 2002:
Vol. 297, Issue 5585, pp. 1243
DOI: 10.1126/science.297.5585.1243a

Need to track down RNA sequences for Ugandan strains of HIV? Want to know the latest mutations that make the virus resistant to drugs? Try searching these HIV molecular and immunological databases from the Los Alamos National Laboratory in New Mexico.

The sequence database lets you sift through thousands of viral sequences by patient's risk factor, country of origin, year, subtype, and other categories. Although protease inhibitors and other drugs have slashed the death rate from AIDS, the shape-shifting virus continually evolves resistance to our best weapons. The site provides a listing of mutations that confer this ability. Another section summarizes procedures and results for more than 100 vaccine trials in nonhuman primates and in people. To find out which parts of the virus draw interest from the immune system, try the Molecular Immunology Database.

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