News of the WeekPAIN RESEARCH

Enzyme Might Relieve Research Headache

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Science  20 Sep 2002:
Vol. 297, Issue 5589, pp. 1976
DOI: 10.1126/science.297.5589.1976a

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How the popular pain reliever acetaminophen works has been largely a mystery. Now a group of biochemists has discovered in dogs a new variant of the well-studied cyclooxygenase (COX) enzyme. The newfound enzyme, dubbed COX-3, fits the profile of the long-sought site of action for the drug, which is the active ingredient in Tylenol.