Neuropeptides and Peptide Hormones in Anopheles gambiae

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Science  04 Oct 2002:
Vol. 298, Issue 5591, pp. 172-175
DOI: 10.1126/science.1076827

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The African malaria mosquito, Anopheles gambiae, is specialized for rapid completion of development and reproduction. A vertebrate blood meal is required for egg production, and multiple feedings subsequently allow transmission of malaria parasites,Plasmodium spp. Regulatory peptides from 35 genes annotated from the A. gambiae genome likely coordinate these and other physiological processes. Plasmodium parasites may affect actions of newly identified insulin-like peptides, which coordinate growth and reproduction of its vector, A. gambiae, as in Drosophila melanogaster,Caenorhabditis elegans, and mammals. This genomic information provides a basis to expand understanding of hematophagy and pathogen transmission in this mosquito.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: mbrown{at}bugs.ent.uga.edu

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