DATABASE: Parse Protein Pedigrees

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Science  11 Oct 2002:
Vol. 298, Issue 5592, pp. 329
DOI: 10.1126/science.298.5592.329b

A new Web site from Hebrew University in Jerusalem aims to simplify the analysis of protein structure and function. Along with the usual sequence information, ProtoNet automatically clusters proteins by similarity, creating a family tree that allows researchers to compare individual proteins or related groups. For more than 100,000 proteins, the site holds a data card that lists each molecule's amino acid sequence, identifies functional regions, and charts the taxonomy of the organism it comes from. You can compare each protein to other members of its immediate family or climb up the tree to contrast different groups, which might help deduce the function of mystery molecules or tease out evolutionary trends. If you don't find your favorite protein here, submit its sequence to find out how it fits into known clusters.

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