DATABASE: Whole Enzyme Catalog

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Science  25 Oct 2002:
Vol. 298, Issue 5594, pp. 709
DOI: 10.1126/science.298.5594.709b

Enzymes are the cell's blue-collar workers, taking on vital jobs such as copying DNA, breaking down food, and defanging toxic metabolites. To track down information on the function, structure, and activity of enzymes, visit BRENDA, a massive database curated by biochemist Dietmar Schomburg and colleagues at the University of Cologne in Germany. The team gleaned from the literature chemical details for some 3500 enzymes and compiled a data-rich biography for each. You can find out, for instance, what reaction the enzyme catalyzes and what compounds inhibit or activate it; where in the cell it works; the optimum temperature and pH for the reaction; how to store a sample; and whether it is implicated in any diseases. Besides enzyme name, you can search the data by function, chemical properties, and other criteria. For academics and researchers at nonprofit organizations, access to BRENDA is free with registration.

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