Special Viewpoints

Neural and Immunological Synaptic Relations

See allHide authors and affiliations

Science  25 Oct 2002:
Vol. 298, Issue 5594, pp. 785-789
DOI: 10.1126/science.1076386

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


A synapse is a stable adhesive junction between two cells across which information is relayed by directed secretion. The nervous system and immune system utilize these specialized cell surface contacts to directly convey and transduce highly controlled secretory signals between their constituent cell populations. Each of these synaptic types is built around a microdomain structure comprising central active zones of exocytosis and endocytosis encircled by adhesion domains. Surface molecules that may be incorporated into and around the active zones contribute to modulation of the functional state of the synapse.

  • * To whom correspondence should be addressed. E-mail: dustin{at}saturn.med.nyu.edu (M.L.D.); david.colman{at}mcgill.ca(D.R.C.)

View Full Text

Stay Connected to Science