PerspectiveSignal Transduction

Decoding NF-κB Signaling

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Science  08 Nov 2002:
Vol. 298, Issue 5596, pp. 1189-1190
DOI: 10.1126/science.1079331

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The master transcription factor NF-kB regulates the expression of many target genes. In their Perspective, Ting and Endy discuss a new experiment-driven quantitative model (Hoffmann et al.) that seeks to explain how the NF-kB/IkB signaling pathway is fine-tuned so that it can switch on a series of early and late genes in response to a stimulus such as tumor necrosis factor.