News of the WeekImmunology

Antibodies Kill by Producing Ozone

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Science  15 Nov 2002:
Vol. 298, Issue 5597, pp. 1319
DOI: 10.1126/science.298.5597.1319

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In work published online today by Science, researchers report evidence that antibodies can catalyze the production of highly active forms of oxygen, likely including ozone. This can not only kill bacterial pathogens directly but might also promote inflammatory and other immune responses. The work puts antibodies in a whole new light, because they weren't previously supposed to have such direct effects.