A Signal Mixing Bowl

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Science  06 Dec 2002:
Vol. 298, Issue 5600, pp. 1849-1851
DOI: 10.1126/science.298.5600.1849e

The parahippocampal region of the brain is important for the integration of memory-related information. Tracing and lesion studies have provided a wealth of morphological data and delineated a cascade of synaptic transactions that carry information from the neocortex to the hippocampus. However, because of difficulties in accessing this region, not much is known about the electrophysiological correlates of these connections. The in vitro isolated guinea pig brain preparation allows for the precise positioning of electrodes in the different subfields that form the parahippocampal region.

Biella et al. analyzed the propagation of electrical activity from the temporal neocortex to the perirhinal and the entorhinal cortices. Information flow from perirhinal areas 35 and 36 to the superficial layers of the entorhinal cortex is not extensive and is spatially scattered. The propagation of this activity is also under strong inhibitory control within the perirhinal cortex. This organizational pattern may facilitate the selection and integration of simultaneously presented inputs from the neocortex. — PRS

J. Neurosci.22, 9972 (2002).

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