PerspectiveMolecular Biology

Untangling Checkpoints

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Science  06 Dec 2002:
Vol. 298, Issue 5600, pp. 1905-1907
DOI: 10.1126/science.1079225

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In response to genotoxic stresses that damage DNA, cells halt at a series of checkpoints during the cell cycle to provide sufficient time for the DNA to be repaired. In a Perspective, Sagata discusses a new study published elsewhere that shows how the kinase Chk1 contributes to S and Gcheckpoints by phosphorylating a key checkpoint phosphatase, Cdc25A.