Organization RINGleader

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Science  13 Dec 2002:
Vol. 298, Issue 5601, pp. 2095
DOI: 10.1126/science.298.5601.2095b

Eukaryotic cells contain a number of vaguely defined supramolecular structures—aptly termed dots, speckles, and bodies—whose functional roles are unclear. The individual proteins found within these structures perform diverse functions, but many possess a small zinc-binding motif called a RING domain. Kentsis et al. report that purified RING domains from several unrelated proteins, including the breast cancer susceptibility gene product 1 (BRCA1) and the promyelocytic leukemia protein (PML), can self-assemble in vitro into high-order structures that resemble those formed in cells. These RING bodies acted as structural scaffolds for multiple partner proteins, raising the possibility that the function of RING domain self-assembly in cells is to integrate biochemical reactions. — PAK

Proc. Natl. Acad. Sci. U.S.A.99, 15404 (2002).

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