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Science  20 Dec 2002:
Vol. 298, Issue 5602, pp. 2327
DOI: 10.1126/science.298.5602.2327b

The Report “Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors” (1) harbors a fundamental inaccuracy. Although the chemical structure of compound 4 is correct as presented, we have not been able to reproduce the biological activity of this compound in the neonatal rat model of chemotherapy-induced alopecia. Thus, we must retract our results. We are continuing to investigate several compounds from another structural class of CDK inhibitors that block chemotherapy-induced alopecia in this model.


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