A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor

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Science  20 Dec 2002:
Vol. 298, Issue 5602, pp. 2392-2395
DOI: 10.1126/science.1076963

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The immunoglobulin G (IgG)–containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal-transducing component, Igα/Igβ. Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22-mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens.

  • * These authors contributed equally to this work.

  • Present address: Department of Biochemistry and Molecular Immunology, University of Bielefeld, D-33615 Bielefeld, Germany.

  • To whom correspondence should be addressed. E-mail: tsubata.imm{at}

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