Remodeling One's Residence

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Science  24 Jan 2003:
Vol. 299, Issue 5606, pp. 475-477
DOI: 10.1126/science.299.5606.475e

Tuberculosis (TB) remains an urgent global health problem, rivaling HIV as a cause of human mortality. Resistance to TB depends on cellular immunity to Mycobacterium tuberculosis, and disease readily takes hold in individuals where this has been compromised by other factors, such as coinfection with HIV.

Geijtenbeek et al. and Tailleux et al. provide evidence that M. tuberculosis binds to the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), which is a C-type lectin that recognizes adhesion molecules involved in the regulation of dendritic cell migration and T cell activation. Both groups observed that mycobacteria entered dendritic cells through engagement of DC-SIGN by a mycobacterial cell wall component, lipoarabinomannan (LAM). Geijtenbeek et al. also found that the interaction between DC-SIGN and LAM induced a counterinflammatory state, in which dendritic cells did not become activated and were stimulated to produce interleukin-10, which can contribute to the suppression of normal T cell responses and the establishment of persistent infection. — SJS

J. Exp. Med.197, 7; 121 (2003).

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