31 January 2003
Vol 299, Issue 5607

About The Cover

Cover image expansion

COVER Pattern of light generated by a "zero-mode" waveguide, a 50-nm hole in a thin aluminum film. Such a waveguide enables observations of single molecules within zeptoliter optical volumes. As described on page 682, single molecules of a DNA polymerase enzyme could be seen to incorporate fluorescent nucleotides, as shown by the cartoon. [Illustration: K. Hodgson]