Obesity Drug Pipeline Not So Fat

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Science  07 Feb 2003:
Vol. 299, Issue 5608, pp. 849-852
DOI: 10.1126/science.299.5608.849

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Why aren't there more antiobesity drugs? For one, such drugs must tamper with the biochemistry of metabolism; it's an essential system for survival and thus sometimes fatal to disrupt. In addition, appetite circuits in the brain use neurotransmitters and receptors that control other body processes. And yet research is beginning to yield important insights into the body's cast of caloric characters (see p. 846).