PerspectiveSignal Transduction

Imposing Specificity on Kinases

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Science  14 Feb 2003:
Vol. 299, Issue 5609, pp. 1025-1027
DOI: 10.1126/science.1081519

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How does a cell imbue kinase signaling cascades that share some of the same components with a specificity that ensures activation of the correct cellular response? In their Perspective, Ptashne and Gann discuss the leading part played by protein scaffolds and regulated recruitment in conferring specificity on kinase signaling cascades.