DATABASE: Networking, Protein Style

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Science  21 Feb 2003:
Vol. 299, Issue 5610, pp. 1159
DOI: 10.1126/science.299.5610.1159b

DNA often gets the glory, but hardworking proteins actually build our bodies and keep them running. Scientists can find out how these blue-collar molecules work together at the Biomolecular Interaction Network Database, sponsored by researchers at several Canadian institutions.

Pick a protein such as insulin, and the database specifies what proteins, nucleic acids, and other molecules it interacts with and how these liaisons were discovered. You can also learn what biochemical pathways a particular protein participates in and whether it belongs to any larger conglomerations of molecules. Users can submit their own information to the database, which so far has information on more than 6200 interactions. The site also features PreBIND, a prototype search engine that scans PubMed for articles that mention proteins likely to interact with your chosen molecule. (The search currently works only for yeast proteins.)

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