Special Reviews

Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

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Science  28 Feb 2003:
Vol. 299, Issue 5611, pp. 1342-1346
DOI: 10.1126/science.1077991

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Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I–like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.

  • * To whom correspondence should be addressed. E-mail: vlongo{at}usc.edu

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