Steroid Control of Longevity in Drosophila melanogaster

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Science  28 Feb 2003:
Vol. 299, Issue 5611, pp. 1407-1410
DOI: 10.1126/science.1080539

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Ecdysone, the major steroid hormone ofDrosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.

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