RESOURCES: Profiling a Supermodel

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Science  21 Mar 2003:
Vol. 299, Issue 5614, pp. 1821
DOI: 10.1126/science.299.5614.1821a

Researchers who use mice to investigate the origin, spread, and treatment of human cancer should scurry over to EMICE, a cache of data on mouse models from the National Cancer Institute. A good starting place is the collection of backgrounders, written by experts, that explicate different kinds of human cancers and describe how mouse models aid research on each variety. If you want more information on specific models, the site will scour PubMed for studies that enlist that animal, or you can paw through the Cancer Models Database, which profiles each type of mouse. Entries explain how researchers made the rodent tumor prone, list tested treatments, and provide histological descriptions of lesions. Collections of links range from protocols on using gene chips to characterize cancer cells to funding providers and breeding centers that supply rodent stocks.

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