Seeing Is Believing

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Science  28 Mar 2003:
Vol. 299, Issue 5615, pp. 2002-2003
DOI: 10.1126/science.1084036

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Many metabolic reactions involve the enzyme-catalyzed transfer of phospho groups, but the intimate detail of such transfers and how they are catalyzed have been unclear. Knowles discusses new, direct, structural information ( Lahiri et al.) that vividly suggests that these reactions proceed by a partly associative in-line mechanism.