Quick Decisions on Catalysts

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Science  04 Apr 2003:
Vol. 300, Issue 5616, pp. 19
DOI: 10.1126/science.300.5616.19c

The development of new polymerization catalysts, especially for specific copolymerizations of two distinct monomers, can be an expensive trial-and-error process. Boussie et al. use microscale, high-throughput primary screening methods to identify 10 candidate catalysts from about 400 trials. Analysis of these screens was carried out by rapid gel permeation chromatography and Fourier-transform infrared spectroscopy methods. From these leads, a hafnium(IV) complex was found to polymerize 1-octene to high conversions. Secondary screens of a 96-member focus library identified a high-temperature ethylene-1-octene copolymerization catalyst.—PDS

J. Am. Chem. Soc. 10.1021/ja020868k (2003).

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