PerspectiveCell Biology

Apoptosis--the Calcium Connection

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Science  04 Apr 2003:
Vol. 300, Issue 5616, pp. 65-67
DOI: 10.1126/science.1083628

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Calcium ions are crucial to many cellular processes including apoptosis. In their Perspective, Demaurex and Distelhorst explain new work that shows how calcium ions flowing between the endoplasmic reticulum (ER) and mitochondria regulate programmed cell death, highlighting the ER as a new gateway to apoptosis ( Scorrano et al.).