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Balancing Selection at the Prion Protein Gene Consistent with Prehistoric Kurulike Epidemics

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Science  25 Apr 2003:
Vol. 300, Issue 5619, pp. 640-643
DOI: 10.1126/science.1083320

Article Information

vol. 300 no. 5619 640-643

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History: 
  • Received for publication February 11, 2003
  • Accepted for publication March 21, 2003
  • .

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Author Information

  1. Simon Mead1,
  2. Michael P. H. Stumpf2,
  3. Jerome Whitfield1,3,
  4. Jonathan A. Beck1,
  5. Mark Poulter1,
  6. Tracy Campbell1,
  7. James B. Uphill1,
  8. David Goldstein2,
  9. Michael Alpers1,3,4,
  10. Elizabeth M. C. Fisher1,
  11. John Collinge1,*
  1. 1 Medical Research Council Prion Unit, and Department of Neurodegenerative Disease, Institute of Neurology, University College, Queen Square, London WC1N 3BG, UK.
  2. 2 Department of Biology (Galton Laboratory), University College London, Gower Street, London WC1E 6BT, UK.
  3. 3 Institute of Medical Research, Goroka, EHP, Papua New Guinea.
  4. 4 Curtin University of Technology, Perth, WA, Australia.
  1. * To whom correspondence should be addressed. E-mail: j.collinge{at}prion.ucl.ac.uk

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