PerspectiveStructural Biology

Changing Partners

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Science  02 May 2003:
Vol. 300, Issue 5620, pp. 755-756
DOI: 10.1126/science.1084854

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Transmembrane proteins called integrins regulate cell adhesion by interacting with both external ligands and internal cytoskeletal proteins. In his Perspective, Hynes explores the molecular changes in the different segments of integrins that contribute to integrin activation and cell adhesion ( Li et al.).