A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity

Elizabeth D. Prescott; David Julius

doi:10.1126/science.1083646

Article Information

vol. 300 no. 5623 1284-1288

DOI:

https://doi.org/10.1126/science.1083646

PubMed:

12764195

Published By:

American Association for the Advancement of Science

Print ISSN:

0036-8075

Online ISSN:

1095-9203

History:

Received for publication February 19, 2003
Accepted for publication April 15, 2003
.

Copyright & Usage:

American Association for the Advancement of Science

Author Information

Elizabeth D. Prescott,
David Julius*

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143–2140, USA.

↵* To whom correspondence should be addressed. E-mail: julius{at}cmp.ucsf.edu

Altmetric

Article usage

Article usage: May 2003 to February 2021

	Abstract	Full	Pdf
May 2003	1176	768	1233
Jun 2003	259	667	572
Jul 2003	151	439	368
Aug 2003	63	189	159
Sep 2003	18	206	166
Oct 2003	31	185	177
Nov 2003	17	163	124
Dec 2003	18	169	145
Jan 2004	37	164	151
Feb 2004	21	131	82
Mar 2004	31	158	114
Apr 2004	37	117	78
May 2004	42	100	65
Jun 2004	50	116	75
Jul 2004	63	117	63
Aug 2004	59	92	40
Sep 2004	41	128	60
Oct 2004	41	130	71
Nov 2004	45	135	70
Dec 2004	75	110	64
Jan 2005	80	143	81
Feb 2005	64	124	56
Mar 2005	62	130	69
Apr 2005	14	110	62
May 2005	33	121	81
Jun 2005	33	75	61
Jul 2005	17	68	42
Aug 2005	39	64	35
Sep 2005	30	72	39
Oct 2005	42	99	57
Nov 2005	47	83	44
Dec 2005	21	53	35
Jan 2006	28	58	41
Feb 2006	32	44	34
Mar 2006	31	59	51
Apr 2006	34	48	39
May 2006	51	82	72
Jun 2006	29	66	50
Jul 2006	37	29	23
Aug 2006	28	34	25
Sep 2006	27	40	27
Oct 2006	40	58	40
Nov 2006	64	68	53
Dec 2006	35	41	31
Jan 2007	41	49	36
Feb 2007	39	40	29
Mar 2007	44	62	44
Apr 2007	51	46	37
May 2007	21	52	38
Jun 2007	30	48	44
Jul 2007	64	33	32
Aug 2007	56	29	28
Sep 2007	225	40	24
Oct 2007	309	39	33
Nov 2007	278	42	29
Dec 2007	349	39	29
Jan 2008	482	33	22
Feb 2008	239	36	24
Mar 2008	179	29	12
Apr 2008	122	41	21
May 2008	168	38	34
Jun 2008	139	38	35
Jul 2008	181	31	24
Aug 2008	193	21	15
Sep 2008	69	35	22
Oct 2008	97	23	24
Nov 2008	66	24	25
Dec 2008	79	22	19
Jan 2009	89	17	15
Feb 2009	103	23	20
Mar 2009	130	29	21
Apr 2009	71	29	14
May 2009	42	19	22
Jun 2009	59	32	20
Jul 2009	20	22	18
Aug 2009	13	13	9
Sep 2009	12	24	23
Oct 2009	24	20	23
Nov 2009	29	29	20
Dec 2009	23	27	18
Jan 2010	19	22	15
Feb 2010	28	18	16
Mar 2010	36	35	24
Apr 2010	27	27	23
May 2010	38	42	18
Jun 2010	16	57	24
Jul 2010	14	48	26
Aug 2010	13	18	12
Sep 2010	15	24	16
Oct 2010	15	27	18
Nov 2010	22	21	19
Dec 2010	36	26	15
Jan 2011	45	28	11
Feb 2011	38	24	20
Mar 2011	63	31	24
Apr 2011	63	20	12
May 2011	64	20	20
Jun 2011	40	12	13
Jul 2011	25	19	13
Aug 2011	45	35	29
Sep 2011	55	41	39
Oct 2011	62	20	35
Nov 2011	63	22	23
Dec 2011	51	13	19
Jan 2012	70	15	17
Feb 2012	49	13	22
Mar 2012	66	4	21
Apr 2012	66	11	18
May 2012	68	12	14
Jun 2012	46	10	17
Jul 2012	37	13	11
Aug 2012	35	13	12
Sep 2012	59	11	13
Oct 2012	59	15	10
Nov 2012	76	30	14
Dec 2012	36	9	6
Jan 2013	27	18	11
Feb 2013	58	18	34
Mar 2013	56	44	24
Apr 2013	40	24	11
May 2013	46	28	20
Jun 2013	34	18	10
Jul 2013	54	23	21
Aug 2013	39	13	9
Sep 2013	60	34	22
Oct 2013	85	28	27
Nov 2013	75	28	26
Dec 2013	72	17	17
Jan 2014	55	20	22
Feb 2014	47	21	19
Mar 2014	52	16	19
Apr 2014	80	27	19
May 2014	96	37	20
Jun 2014	76	17	13
Jul 2014	77	21	22
Aug 2014	33	16	18
Sep 2014	56	27	15
Oct 2014	69	25	13
Nov 2014	37	14	14
Dec 2014	32	17	7
Jan 2015	47	16	12
Feb 2015	30	14	14
Mar 2015	43	24	17
Apr 2015	57	24	29
May 2015	45	23	16
Jun 2015	26	14	9
Jul 2015	32	18	13
Aug 2015	26	9	8
Sep 2015	36	14	14
Oct 2015	30	17	12
Nov 2015	36	10	10
Dec 2015	53	7	4
Jan 2016	37	5	6
Feb 2016	52	11	12
Mar 2016	75	5	10
Apr 2016	67	8	17
May 2016	66	7	14
Jun 2016	61	9	15
Jul 2016	54	5	12
Aug 2016	49	12	12
Sep 2016	50	9	13
Oct 2016	61	6	15
Nov 2016	46	3	7
Dec 2016	50	11	12
Jan 2017	46	4	1
Feb 2017	43	10	6
Mar 2017	38	4	6
Apr 2017	41	10	14
May 2017	37	9	11
Jun 2017	41	6	9
Jul 2017	33	5	6
Aug 2017	48	2	16
Sep 2017	43	7	16
Oct 2017	62	11	22
Nov 2017	60	13	15
Dec 2017	27	7	11
Jan 2018	47	6	9
Feb 2018	44	6	18
Mar 2018	39	16	14
Apr 2018	46	11	9
May 2018	55	14	13
Jun 2018	43	12	4
Jul 2018	33	9	20
Aug 2018	32	27	19
Sep 2018	30	17	6
Oct 2018	25	30	14
Nov 2018	38	21	4
Dec 2018	36	11	4
Jan 2019	31	25	18
Feb 2019	19	15	14
Mar 2019	19	31	10
Apr 2019	28	25	9
May 2019	21	15	8
Jun 2019	20	18	10
Jul 2019	26	18	10
Aug 2019	27	15	8
Sep 2019	21	14	9
Oct 2019	31	16	6
Nov 2019	15	23	7
Dec 2019	44	12	5
Jan 2020	31	17	11
Feb 2020	13	13	7
Mar 2020	28	16	8
Apr 2020	38	15	5
May 2020	25	14	4
Jun 2020	46	19	6
Jul 2020	26	14	15
Aug 2020	33	17	11
Sep 2020	49	38	15
Oct 2020	29	23	6
Nov 2020	31	24	9
Dec 2020	22	13	5
Jan 2021	29	27	9
Feb 2021	23	15	4

View Full Text

A Modular PIP₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity

Article Information

Author Information

Altmetric

Article usage

Article usage: May 2003 to February 2021

Science

Article Tools

A Modular PIP₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity

Citation Manager Formats

A Modular PIP₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity

My saved folders

Stay Connected to Science

Citing Articles in:

share

Article Information

Author Information

Altmetric

Article usage

Article usage: May 2003 to February 2021

Science

Article Tools

A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity

Citation Manager Formats

A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity

My saved folders

Stay Connected to Science

Related Content

Similar Articles in:

Citing Articles in:

Read the Latest Issue of Science

26 February 2021

Feature

Science and Society

Astrobiology

SCI COMMUN

Geophysics

Working Life

A Modular PIP₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity

A Modular PIP₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity