DATABASE: HIV's Achilles Heel

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Science  30 May 2003:
Vol. 300, Issue 5624, pp. 1349
DOI: 10.1126/science.300.5624.1349d

Without the enzyme protease, which chops newly manufactured viral proteins into useable strands, HIV can't replicate. Aimed at everyone from drug designers hoping to concoct more efficient blockers to students studying protein chemistry, the HIV Protease Database presents 3D structures of the crucial enzyme alone or coupling with inhibitors. Hosted by the National Institute of Standards and Technology, the collection holds measurements from more than 200 studies of HIV and SIV, the simian variant of the virus. You can search for structures by type or strain of virus, inhibitor, resolution, and other criteria, or troll a list of proteases from drug-resistant mutants. Although the database includes some info also stored in the Protein Data Bank, it also features results not available elsewhere.

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