Research Article

Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

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Science  30 May 2003:
Vol. 300, Issue 5624, pp. 1394-1399
DOI: 10.1126/science.1085952


In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratorysyndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to anyof the previouslycharacterized coronaviruses.

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