PerspectiveMolecular Biology

A Self-Help Guide for a Trim Genome

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Science  06 Jun 2003:
Vol. 300, Issue 5625, pp. 1517-1518
DOI: 10.1126/science.1086053

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Organisms have developed a range of mechanisms to protect their genomes from being usurped by selfish DNAs such as transposons. In a Perspective, Selker describes an efficient genome defense system in the ciliated protozoan Tetrahymena that prevents unnecessary DNA sequences from being amplified in the workhorse nucleus (macronucleus) of this organism ( Yao et al.).