Mitotic Regulator on the Move

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Science  13 Jun 2003:
Vol. 300, Issue 5626, pp. 1625
DOI: 10.1126/science.300.5626.1625b

The cyclin-dependent kinase Cdc2 is usually thought of as a promoter of mitosis. Manes et al. describe a possible role for Cdc2 in regulating cell migration. Expression of the membrane protein αVβ3 integrin is associated with migratory and invasive behaviors of some cancer cells, and Cdc2 levels were elevated in a prostate cancer cell line overexpressing αVβ3 integrin. Ectopic expression of Cdc2 increased migration in cell lines; conversely, inhibition of Cdc2 activity by expression of a dominant negative or with pharmacological inhibitors reduced migration of cultured cells. Prostate cancers often show increased expression of αVβ3 integrin, and increased expression of Cdc2 in prostate cancer correlates with more aggressive cancers. Thus, the authors note that key actions of Cdc2 in this instance may occur through promotion of migration and invasion rather than through the more customary role of promoting cell proliferation.—LBR

J. Cell Biol. 161, 817 (2003).

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