DATABASE: A Parasite's Chemical Flowchart

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Science  13 Jun 2003:
Vol. 300, Issue 5626, pp. 1633
DOI: 10.1126/science.300.5626.1633d

This database from Hebrew University in Jerusalem compiles many of the biochemical pathways that keep the malaria parasite alive and demolishing red blood cells. More than 20 interactive diagrams trace the chemical changes that allow the Plasmodium parasite to slice up glucose, synthesize the building blocks of proteins and DNA, and break down the hemoglobin the bug purloins from its victims. Click on the substrates to get their chemical structure and molecular weight. Enzymes link to protein databases and to PlasmoDB, which holds the parasite's genome sequence, which was completed last fall.

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