PerspectiveCircadian Rhythms

Clocks on the Brain

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Science  18 Jul 2003:
Vol. 301, Issue 5631, pp. 319-320
DOI: 10.1126/science.1087824

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In many animals, circadian oscillators in the brain and periphery synchronize gene expression and behavior with the 24-hour day:night cycle. In their Perspective, Green and Menaker discuss new work ( Dudley et al.), which shows that the master oscillator in the hypothalamus, the suprachiasmatic nucleus, cooperates with an oscillator in the forebrain to synchronize circadian behavior in mice.