DATABASE: The Lowdown on a Killer Bug

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Science  25 Jul 2003:
Vol. 301, Issue 5632, pp. 443
DOI: 10.1126/science.301.5632.443d

Tuberculosis, the disease that slayed John Keats, Jane Austen, and George Orwell, remains a leading killer, responsible for about 2 million deaths worldwide every year. Researchers working to foil the evasive TB bacterium can round up plenty of information on its genes and proteins at TubercuList, a genomic database from the Pasteur Institute in Paris. The site brims with data on some 4000 genes from Mycobacterium tuberculosis. Pick a gene and learn the function of the protein it encodes, call up a map showing its chromosomal location, or pinpoint nearby genes. Each entry also lists relevant references and lets you download the gene's DNA sequence or the amino acid sequence of its protein for further analysis.

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