01 August 2003
Vol 301, Issue 5633

About The Cover

Cover image expansion

COVER Model of the lactose permease of Escherichia coli (LacY) in its inward-facing conformation, with a large hydrophilic cavity open to the cytoplasmic surface at the top. The substrate-binding site (bound sugar shown in gold) is at a similar distance from either side of the membrane (blue-gray). LacY catalyzes the concomitant translocation of a galactoside and a proton across the membrane, as described on page 610. [Image: S. Iwata]