Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Luca Santarelli; Michael Saxe; Cornelius Gross; Alexandre Surget; Fortunato Battaglia; Stephanie Dulawa; Noelia Weisstaub; James Lee; Ronald Duman; Ottavio Arancio; Catherine Belzung; René Hen

doi:10.1126/science.1083328

Research Article

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Luca Santarelli1,*,
Michael Saxe1,*,
Cornelius Gross1,
Alexandre Surget2,
Fortunato Battaglia3,
Stephanie Dulawa1,
Noelia Weisstaub1,
James Lee1,
Ronald Duman4,
Ottavio Arancio3,
Catherine Belzung2,
René Hen1,†

¹ Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
² Psychobiologie des Emotions, Université François Rabelais, Tours 37200, France.
³ Nathan Kline Research Institute, New York University School of Medicine, New York, NY 10016, USA.
⁴ Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University, New Haven, CT 06508, USA.

↵† To whom correspondence should be addressed. E-mail: rh95{at}columbia.edu

↵* These authors contributed equally to this work.

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Science 08 Aug 2003:
Vol. 301, Issue 5634, pp. 805-809
DOI: 10.1126/science.1083328

Luca Santarelli

1 Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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Michael Saxe

1 Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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Cornelius Gross

1 Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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Alexandre Surget

2 Psychobiologie des Emotions, Université François Rabelais, Tours 37200, France.

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Fortunato Battaglia

3 Nathan Kline Research Institute, New York University School of Medicine, New York, NY 10016, USA.

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Stephanie Dulawa

1 Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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Noelia Weisstaub

1 Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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James Lee

1 Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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Ronald Duman

4 Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University, New Haven, CT 06508, USA.

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Ottavio Arancio

3 Nathan Kline Research Institute, New York University School of Medicine, New York, NY 10016, USA.

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Catherine Belzung

2 Psychobiologie des Emotions, Université François Rabelais, Tours 37200, France.

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René Hen

1 Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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For correspondence: rh95@columbia.edu

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