Targeting Prostate Cancer via G Proteins

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Science  17 Oct 2003:
Vol. 302, Issue 5644, pp. 361
DOI: 10.1126/science.302.5644.361b

Prostate cancer typically starts as an androgen-dependent tumor, but then can progress to androgen independence. Bookout et al. investigated the role of heterotrimeric guanine nucleotide-binding proteins (G proteins), specifically the βγ subunits, in androgen-independent tumor growth in culture and in vivo. Androgen-independent PC3 human prostate cancer cells exhibited increased apoptosis when treated with recombinant adenovirus to induce expression of a Gβγ inhibitor, a peptide from the C terminus of G protein-coupled receptor kinase 2 (GRK2ct). Furthermore, injection of adenovirus carrying GRK2ct into PC3 tumors established in athymic mice slowed tumor growth and promoted apoptosis in the region adjacent to the injection site. Thus, inhibition of G protein signaling may represent another strategy for treatment of androgen-independent prostate cancer. — NG

J. Biol. Chem. 278, 37569 (2003).

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