PerspectiveMolecular Biology

MeCP2 Repression Goes Nonglobal

See allHide authors and affiliations

Science  31 Oct 2003:
Vol. 302, Issue 5646, pp. 793-795
DOI: 10.1126/science.1091762

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Methylation of CpG islands in gene promoters results in silencing of those genes. Mutation of a methyl-CpG binding domain protein called MeCP2 that contributes to the maintenance of methylation-mediated gene silencing is associated with a severe neurological disease called Rett syndrome. As Klose and Bird report in their Perspective, new work published here ( Chen et al., Martinowich et al.) and elsewhere demonstrates that MeCP2 normally represses the expression of two genes- BDNF in rat and Hairy2a in frog-that are crucial for normal development of the nervous system.